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Overall stability for the ibuprofen racemate: experimental and topological results leading to the pressure-temperature phase relationships between its racemate and conglomerate

Autor
Rietveld, I.; Del Barrio, M.; Do, B.; Tamarit, J. Ll.; Céolin, R.
Tipus d'activitat
Article en revista
Revista
Journal of physical chemistry B
Data de publicació
2012-05-10
Volum
116
Número
18
Pàgina inicial
5568
Pàgina final
5574
DOI
https://doi.org/10.1021/jp302508g Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/16161 Obrir en finestra nova
URL
http://pubs.acs.org/doi/pdf/10.1021/jp302508g Obrir en finestra nova
Resum
Enantiomer resolution is much sought after for pharmaceutical applications, because many optically active drug molecules have only one pharmaceutically active enantiomer. Although it is always possible to force separation, it will come at a cost. The present method, based on thermodynamics, provides a relatively easy approach to investigate whether separation can be thermodynamically spontaneous. A topological phase diagram of the binary enantiomer system at 0.5 mol-fraction is constructed as a ...
Citació
Rietveld, I. [et al.]. Overall stability for the ibuprofen racemate: experimental and topological results leading to the pressure-temperature phase relationships between its racemate and conglomerate. "Journal of physical chemistry B", 10 Maig 2012, vol. 116, núm. 18, p. 5568-5574.
Paraules clau
Enantiomer resolution, Monotropy, Optically Active, Pharmaceutical applications, Phase relationships, Solid forms, Topological phase
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants