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Crystal structure of a complex of DNA with one AT-hook of HMGA1

Autor
Fonfria, E.; Acosta, F.J.; Saperas, N.; Pous, J.; Subirana, J.; Campos, J.Lourdes
Tipus d'activitat
Article en revista
Revista
PloS one
Data de publicació
2012-05-16
Volum
7
Número
5
Pàgina inicial
1
Pàgina final
5
DOI
https://doi.org/10.1371/journal.pone.0037120 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/16654 Obrir en finestra nova
URL
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037120 Obrir en finestra nova
Resum
We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)2, which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT-hook forms hydrogen bonds between main-chain NH groups and thymines in the minor groove, DNA is bent and...
Citació
Fonfria, E. [et al.]. Crystal structure of a complex of DNA with one AT-hook of HMGA1. "PLoS One", 16 Maig 2012, vol. 7, núm. 5, p. 1-5.
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques

Participants

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