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Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles

Autor
Lanz, A.; Garcia, M.; Portilla, J.A.; Martinez de Ilarduya, A.; Holler, E.; Ljubimova, J.; Muñoz, S.
Tipus d'activitat
Article en revista
Revista
Macromolecular chemistry and physics
Data de publicació
2012-08-14
Volum
213
Número
15
Pàgina inicial
1623
Pàgina final
1631
DOI
https://doi.org/10.1002/macp.201200134 Obrir en finestra nova
Projecte finançador
POLÍMEROS Y NANOPOLÍMEROS DE FUENTES RENOVABLES PARA APLICACIONES BIOMÉDICAS
Repositori
http://hdl.handle.net/2117/16855 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/macp.201200134/full Obrir en finestra nova
Resum
Microbial poly( β , L -malic acid) was modifi ed with either L -leucine ethyl ester (L) or L -phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis-precipitation method. N...
Citació
Lanz, A. [et al.]. Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles. "Macromolecular chemistry and physics", 14 Agost 2012, vol. 213, núm. 15, p. 1623-1631.
Grup de recerca
POL - Polímers Industrials Avançats i Biopolímers Tecnològics

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