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Osteoblast-like cellular response to dynamic changes in the ionic extracellular environment produced by calcium-deficient hydroxyapatite

Autor
Gustavsson, J.; Ginebra, M.P.; Planell, J. A.; Engel, E.
Tipus d'activitat
Article en revista
Revista
Journal of materials science. Materials in medicine
Data de publicació
2012-10
Volum
23
Número
10
Pàgina inicial
2509
Pàgina final
2520
DOI
https://doi.org/10.1007/s10856-012-4705-4 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/19727 Obrir en finestra nova
Resum
Solution-mediated reactions due to ionic substitutions are increasingly explored as a strategy to improve the biological performance of calcium phosphate-based materials. Yet, cellular response to well-defined dynamic changes of the ionic extracellular environment has so far not been carefully studied in a biomaterials context. In this work, we present kinetic data on how osteoblast-like SAOS-2 cellular activity and calcium-deficient hydroxyapatite (CDHA) influenced extracellular pH as well as e...
Citació
Gustavsson, J. [et al.]. Osteoblast-like cellular response to dynamic changes in the ionic extracellular environment produced by calcium-deficient hydroxyapatite. "Journal of materials science. Materials in medicine", Octubre 2012, vol. 23, núm. 10, p. 2509-2520.
Paraules clau
Alkaline-phosphatase Activity, Saos-2 Cells, In-vitro, Bone Mineralization, Biological Basis, Differentiation, Culture, Matrix, Proliferation, Topography
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants