b-type titanium alloys with low Young’s modulus
are desirable to reduce stress shielding effect and enhance
bone remodeling for implants used to substitute failed hard
tissue. For biomaterials application, the surface bioactivity is
necessary to achieve optimal osseointegration. In the previous
work, the low elastic modulus (43 GPa) Ti-25Nb-16Hf (wt
%) alloy was mechanically and microstructurally characterized.
In the present work, the biological behavior of Ti-25Nb-
16Hf was studied. The biol...
b-type titanium alloys with low Young’s modulus
are desirable to reduce stress shielding effect and enhance
bone remodeling for implants used to substitute failed hard
tissue. For biomaterials application, the surface bioactivity is
necessary to achieve optimal osseointegration. In the previous
work, the low elastic modulus (43 GPa) Ti-25Nb-16Hf (wt
%) alloy was mechanically and microstructurally characterized.
In the present work, the biological behavior of Ti-25Nb-
16Hf was studied. The biological response was improved by
surface modification. The metal surface was modified by oxygen
plasma and subsequently silanized with 3-chloropropyl
(triethoxy)silane for covalent immobilization of the elastin-like
polymer. The elastin-like polymer employed exhibits RGD bioactive
motives inspired to the extracellular matrix in order to
improve cell adhesion and spreading. Upon modification, the
achieved surface presented different physical and chemical
properties, such as surface energy and chemical composition.
Subsequently, osteoblast adhesion, cell numbers, and differentiation
studies were performed to correlate surface properties
and cell response. The general tendency was that the
higher surface energy the higher cell adhesion. Furthermore,
cell culture and immunofluorescence microscopy images demonstrated
that RGD-modified surfaces improved adhesion and
spreading of the osteoblast cell type.
Citació
González, M. [et al.]. A low elastic modulus Ti-Nb-Hf alloy bioactivated with an elastin-like. "Journal of biomedical materials research. Part A", 2012, vol. 00A, p. 000.
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