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Effects of ring contraction on the conformational preferences of a-substituted proline analogs

Autor
Revilla-López, G.; Warren, J.G.; Torras, J.; Jimenez, A.; Cativiela, C.; Aleman, C.
Tipus d'activitat
Article en revista
Revista
Biopolymers
Data de publicació
2012-03-01
Volum
98
Número
2
Pàgina inicial
98
Pàgina final
110
DOI
https://doi.org/10.1002/bip.21716 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/17488 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/bip.21716/abstract Obrir en finestra nova
Resum
The structural consequences derived from the incorporation of either a methyl or a phenyl group at the a carbon of proline were recently investigated by quantum mechanical calculations (J Org Chem 2008, 73, 3418). In this work, the effect produced by contraction of the pyrrolidine ring on such a-substituted proline analogs has been explored using the same computational methods. Specifically, the intrinsic conformational preferences of the N-acetyl-N 0 -methylamide derivatives of the lower prolin...
Citació
Revilla-López, G. [et al.]. Effects of ring contraction on the conformational preferences of a-substituted proline analogs. "Biopolymers", 01 Març 2012, vol. 98, núm. 2, p. 98-110.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants