Carregant...
Carregant...

Vés al contingut (premeu Retorn)

The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche

Autor
Álvarez, Z.; Mateos, M.; Hyroššová, P.; Castaño, O.; Planell, J. A.; Perales, J.; Engel, E.; Alcántara, S.
Tipus d'activitat
Article en revista
Revista
Biomaterials
Data de publicació
2013-03-06
Volum
34
Número
9
Pàgina inicial
2221
Pàgina final
2233
DOI
https://doi.org/10.1016/j.biomaterials.2012.12.001 Obrir en finestra nova
Projecte finançador
MAT 2008-06887-C03-03 - Superficies poliméricas biofuncionalizadas para regeneración tisular.
Repositori
http://hdl.handle.net/2117/20906 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0142961212013671# Obrir en finestra nova
Resum
To develop tissue engineering strategies useful for repairing damage in the central nervous system (CNS) it is essential to design scaffolds that emulate the NSC niche and its tight control of neural cell genesis, growth, and differentiation. In this study we tested two types of poly l/dl lactic acid (PLA95/5 and PLA70/30), a biodegradable material permissive for neural cell adhesion and growth, as materials for nerve regeneration. Both PLA were slightly hydrophobic and negatively charged but di...
Citació
Álvarez, Z. [et al.]. The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche.. "Biomaterials", 06 Març 2013, vol. 34, núm. 9, p. 2221-2233.
Paraules clau
Degradation, Glial Cells, Lactate, Neurons, Nsc Niche, Polylactic Acid, Progenitors
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica

Participants