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The effect of sustained compression on oxygen metabolic transport in the intervertebral disc decreases with degenerative changes

Autor
Malandrino, A.; Noailly, J.; Damien, D.
Tipus d'activitat
Article en revista
Revista
PLOS computational biology
Data de publicació
2011-08-04
Volum
7
Número
8
Pàgina inicial
1
Pàgina final
12
DOI
https://doi.org/10.1371/journal.pcbi.1002112 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/18529 Obrir en finestra nova
Resum
Intervertebral disc metabolic transport is essential to the functional spine and provides the cells with the nutrients necessary to tissue maintenance. Disc degenerative changes alter the tissue mechanics, but interactions between mechanical loading and disc transport are still an open issue. A poromechanical finite element model of the human disc was coupled with oxygen and lactate transport models. Deformations and fluid flow were linked to transport predictions by including strain-dependent d...
Citació
Malandrino, A.; Noailly, J.; Damien, D. The effect of sustained compression on oxygen metabolic transport in the intervertebral disc decreases with degenerative changes. "PLOS computational biology", 04 Agost 2011, vol. 7, núm. 8, p. 1-12.
Grup de recerca
BIOMEC - Biomechanical Engineering Lab

Participants

  • Malandrino, Andrea  (autor)
  • Noailly, Jerome  (autor)
  • Lacroix, Damien  (autor)

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