Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Dependency of calcium alternans on Ryanodine Receptor Refractoriness

Autor
Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Cinca, J.; Hove-Madsen, L.; Echebarria, B.
Tipus d'activitat
Article en revista
Revista
PloS one
Data de publicació
2013-02-04
Volum
8
Número
2
DOI
https://doi.org/10.1371/journal.pone.0055042 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/18961 Obrir en finestra nova
URL
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055042 Obrir en finestra nova
Resum
Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) Methodology/Principal Findings To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis u used a mathematical rabbit cardiomyocyte model to study the beat-to-beat calcium response as a function of RyR were ...
Citació
Alvarez-Lacalle, E. [et al.]. Dependency of calcium alternans on Ryanodine Receptor Refractoriness. "PLoS One", 04 Febrer 2013, vol. 8, núm. 2.
Paraules clau
EMTREE drug terms: ryanodine receptor 2 EMTREE medical terms: article, beat to beat calcium response, calcium cell level, calcium current, calcium loading, calcium signaling, calcium transport, channel gating, chemical parameters, computer model, controlled study, cytosolic calcium alternans, heart muscle cell, mathematical model, molecular dynamics, nonhuman, predictive value, rabbit, receptor activation, receptor inactivation, receptor refractoriness, sarcoplasmic reticulum, validation process
Grup de recerca
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació

Participants