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Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes

Autor
Barriga, M.; Cal, R.; Cabello, N.; Llach, A.; Vallmitjana, A.; Benitez, R.; Badimon, L.; Llorente-Cortés, V.; Cinca, J.; Hove-Madsen, L.
Tipus d'activitat
Article en revista
Revista
PLoS one
Data de publicació
2013-03-13
Volum
8
Número
3
Pàgina inicial
1
Pàgina final
10
DOI
https://doi.org/10.1371/journal.pone.0058128 Obrir en finestra nova
Projecte finançador
DESARROLLO DE TÉCNICAS DE ANÁLISIS DE SITEMAS COMPLEJOS PARA EL ESTUDIO DE PROBLEMAS EN FISIOLOGÍA CARDÍACA
Repositori
http://hdl.handle.net/2117/18515 Obrir en finestra nova
URL
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058128 Obrir en finestra nova
Resum
The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the hypothesis that Low Density Lipoprotein (LDL) cholesterol affects calcium dynamics and signal propagation in cultured atrial myocytes. For this purpose, mRNA and protein expression levels were determined by real time PCR and western blot analysis, respectively, and intracellular c...
Citació
Barriga, M. [et al.]. Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes. "PLoS One", 13 Març 2013, vol. 8, núm. 3.
Paraules clau
Smooth-muscle-cells, Human Atrial-fibrillation, Ventricular-fibrillation, Sarcoplasmic-reticulum, Myocytes, Protein, Arrhythmias, Simvastatin, Receptors, Junctions
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
CREB - Centre de Recerca en Enginyeria Biomedica

Participants

  • Barriga, Montserrat  (autor)
  • Cal, Roi  (autor)
  • Cabello, Núria  (autor)
  • Llach, Anna  (autor)
  • Vallmitjana Lees, Alexander  (autor)
  • Benitez Iglesias, Raul  (autor)
  • Badimon, Lina  (autor)
  • Llorente Cortés, Vicenta  (autor)
  • Cinca Cuscullola, Juan Maria  (autor)
  • Hove-Madsen, Leif  (autor)

Arxius