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Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor

Autor
Zanuy, D.; Kotla, R.; Nussinov, R.; Teesalu, T.; Sugahara, K.; Aleman, C.; Haspel
Tipus d'activitat
Article en revista
Revista
Journal of structural biology
Data de publicació
2013-02-24
Volum
182
Número
2
Pàgina inicial
78
Pàgina final
86
DOI
https://doi.org/10.1016/j.jsb.2013.02.006 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/19027 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1047847713000439 Obrir en finestra nova
Resum
Neuropilin-1 (NRP-1) is a hub receptor that plays an essential role in angiogenesis and vascular perme- ability. It is over-expres sed in the new blood vessels grown by tumor cells and is a target for anti-tumor treatment s. Peptides that expose the consensus sequence R/K/ XX R/K at the C-terminus ( C-end rule or CendR peptides) bind to NRP-1 and are internalized into the cell. We used peptide phage display binding assays and molecular dynamics (MD) simulations to study the potential role of the...
Citació
Zanuy, D. [et al.]. Journal of Structural Biology. "Journal of structural biology", 24 Febrer 2013, vol. 182, p. 78-86.
Paraules clau
Binding affinity, CendR peptide, Molecular dynamics, Neuropilin-1
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants