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Modular polylactic acid microparticle-based scaffolds prepared via microfluidic emulsion/solvent displacement process: Fabrication, characterization, and in vitro mesenchymal stem cells interaction study

Autor
Salerno, A.; Levato, R.; Mateos, M.; Engel, E.; Netti, P.; Planell, J. A.
Tipus d'activitat
Article en revista
Revista
Journal of biomedical materials research. Part A
Data de publicació
2012-08-31
Volum
101
Número
3
Pàgina inicial
720
Pàgina final
732
DOI
https://doi.org/10.1002/jbm.a.34374 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/19029 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34374/full Obrir en finestra nova
Resum
The present study reports a novel approach for the design and fabrication of polylactic acid (PLA) microparticle- based scaffolds with microstructural properties suitable for bone and cartilage regeneration. Macroporous PLA scaffolds with controlled shape were fabricated by means of a semicon- tinuous process involving (1) microfluidic emulsification of a PLA/ethyl lactate solution (5% w/v) in a span 80/paraffin oil so- lution (3% v/v) followed by (2) particles coagulation/assembly in an acetone...
Citació
Salerno, A. [et al.]. Modular polylactic acid microparticle-based scaffolds prepared via microfluidic emulsion/solvent displacement process: Fabrication, characterization, and in vitro mesenchymal stem cells interaction study. "Journal of biomedical materials research. Part A", 31 Agost 2012, vol. 101, núm. 3, p. 720-732.
Paraules clau
green solvent, microfluidic, microstructure, scaffold, stem cells
Grup de recerca
CREB - Centre de Recerca en Enginyeria Biomedica
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants