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Effect of genetic regions on the correlation between single point mutation variability and morbidity

Autor
Brunel, H.; Gallardo, J.; Vallverdu, M.; Caminal, P.; Perera, A.
Tipus d'activitat
Article en revista
Revista
Computers in biology and medicine
Data de publicació
2013-06-01
Volum
43
Número
5
Pàgina inicial
594
Pàgina final
599
DOI
https://doi.org/10.1016/j.compbiomed.2013.01.017 Obrir en finestra nova
Resum
Cross-species sequence comparisons have suggested that cross-species sequence variability is correlated with functionality. The goal of this study was to extend this observation at different genetic regions, focusing on the morbidity of Single Nucleotide Polymorphisms (SNPs). A set of deleterious SNPs was compared to a set of neutral SNPs. Both samples were stratified according to the location of the SNPs at different genetic regions. Deleterious SNPs were observed to be less variable across spe...
Paraules clau
Snp, Sequence Variability, Homology, Morbidity, Genetic Regions
Grup de recerca
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Centre de Recerca en Enginyeria Biomedica

Participants