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Improved Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin by Specific Interaction with Docosahexaenoic Acid Phospholipid

Autor
Sanchez, M.; Ramon, E.; Torrent, J.; Torrent-Burgués, J.; Garriga, P.
Tipus d'activitat
Article en revista
Revista
Chembiochem
Data de publicació
2013-03
Volum
14
Número
5
Pàgina inicial
639
Pàgina final
644
DOI
https://doi.org/10.1002/cbic.201200687 Obrir en finestra nova
Resum
Rhodopsin is the photoreceptor located in the rod cells of the retina. It has seven transmembrane helices and is a prototypic member of the G protein-coupled receptor superfamily. The structures and functions of these receptors are clearly affected by the lipid composition of the cell membrane, and their study in a purified recombinant form is usually performed in detergent solution. There is a need to study these receptors in a physiologically relevant environment because the lipid environment ...
Paraules clau
Adsorption isotherm, Fluorescence spectroscopy, Insertion into lipid monolayers, Liposomes, Phospholipids, Rhodopsin
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants