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Quantitative imaging of microtubule alteration as an early marker of axonal degeneration after ischemia in neurons

Autor
Psilodimitrakopoulos, S.; Petegnief, V.; de Vera, N.; Hernandez, O.; Artigas, D.; Planas, A.M.; Loza, P.
Tipus d'activitat
Article en revista
Revista
Biophysical journal
Data de publicació
2013-03-05
Volum
104
Número
5
Pàgina inicial
968
Pàgina final
975
DOI
https://doi.org/10.1016/j.bpj.2013.01.020 Obrir en finestra nova
URL
http://apps.webofknowledge.com/InboundService.do?SID=1EHFalFmaPp%40Ok9go3F&product=WOS&UT=000315748800005&SrcApp=EndNoteWeb&DestFail=http%3A%2F%2Fwww.webofknowledge.com&Init=Yes&action=retrieve&Func=Frame&customersID=ISIResearchSoft&SrcAuth=ISIResearchSoft&IsProductCode=Yes&mode=FullRecord Obrir en finestra nova
Resum
Neuronal death can be preceded by progressive dysfunction of axons. Several pathological conditions such as ischemia can disrupt the neuronal cytoskeleton. Microtubules are basic structural components of the neuronal cytoskeleton that regulate axonal transport and neuronal function. Up-to-date, high-resolution observation of microtubules in living neuronal cells is usually accomplished using fluorescent-based microscopy techniques. However, this needs exogenous fluorescence markers to produce th...
Paraules clau
2ND-HARMONIC GENERATION MICROSCOPY, COLLAGEN, FOCAL CEREBRAL-ISCHEMIA, GLUCOSE DEPRIVATION, MYOSIN, ORGANIZATION, ORIENTATION, POLARIZATION SHG MICROSCOPY, PROTEOLYSIS, TAU PHOSPHORYLATION
Grup de recerca
FOTONICA - Grup de Recerca de Fotònica

Participants

  • Psilodimitrakopoulos, Sotiris  (autor)
  • Petegnief, Valerie  (autor)
  • de Vera, Nuria  (autor)
  • Hernandez, Oscar  (autor)
  • Artigas Garcia, David  (autor)
  • Planas, Ana Maria  (autor)
  • Loza Alvarez, Pablo  (autor)