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Molecular determinants of the bacterial resistance to fluoroquinolones: A computational study

Autor
Lupala, C.; Gomez, P.; Perez, J.
Tipus d'activitat
Article en revista
Revista
Current Computer-Aided Drug Design
Data de publicació
2013-06-13
Volum
9
Número
2
Pàgina inicial
281
Pàgina final
288
DOI
https://doi.org/10.2174/15734099113099990004 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/19563 Obrir en finestra nova
URL
http://www.eurekaselect.com/111590/article Obrir en finestra nova
Resum
Abstract: Quinolones constitute a large class of antibacterial agents whose action is mediated through the formation of a ternary complex with DNA and either, DNA Gyrase or topoisomerase IV, resulting in the inhibition of DNA replication. In order to get a deeper insight into the features of the complex formation, we carried out docking studies of fifteen diverse quinolones to the cleaved topoisomerase IV-DNA complex. Docking studies were performed using the crystal structures of the cleaved com...
Citació
Lupala, C.; Gomez-Gutierrez, P.; Perez, J. Molecular determinants of the bacterial resistance to fluoroquinolones: A computational study. "Current Computer-Aided Drug Design", 13 Juny 2013, vol. 9, núm. 2, p. 281-288.
Paraules clau
antibiotic resistance, antibiotics, quinolones, topoisomerases IV
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
ENGMOL - Enginyeria Molecular

Participants

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