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Liquid-liquid miscibility gaps in drug-water binary systems: crystal Structure and thermodynamic properties of prilocaine and the temperature-composition phase diagram of the prilocaine-water system

Autor
Rietveld, I.; Perrin, J.; Toscani, S.; Del Barrio, M.; Nicolaï, B.; Tamarit, J. Ll.; Céolin, R.
Tipus d'activitat
Article en revista
Revista
Molecular pharmaceutics
Data de publicació
2013-04
Volum
10
Número
4
Pàgina inicial
1332
Pàgina final
1339
DOI
https://doi.org/10.1021/mp300542k Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/19695 Obrir en finestra nova
Resum
EMLA cream, a “eutectic mixture of local anesthetics”, was developed in the early 1980s by Astra Pharmaceutical Production. The mixture of anesthetics containing lidocaine, prilocaine, and water is liquid at room temperature, which is partly due to the eutectic equilibrium between prilocaine and lidocaine at 293 K, as was clear from the start. However, the full thermodynamic background for the stability of the liquid and its emulsion-like appearance has never been elucidated. In the present ...
Citació
Rietveld, I.R. [et al.]. Liquid-liquid miscibility gaps in drug-water binary systems: crystal Structure and thermodynamic properties of prilocaine and the temperature-composition phase diagram of the prilocaine-water system. "Molecular pharmaceutics", Abril 2013, vol. 10, núm. 4, p. 1332-1339.
Paraules clau
Crystal structure, EMLA cream, local anesthetic, phase behavior, physical properties, thermodynamics
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants