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Quality control system response to stochastic growth of amyloid fibrils

Autor
Pigolotti, S.; Lizana, L.; Otzen, D.; Sneppen, K.
Tipus d'activitat
Article en revista
Revista
Febs letters
Data de publicació
2013-05-02
Volum
587
Número
9
Pàgina inicial
1405
Pàgina final
1410
DOI
https://doi.org/10.1016/j.febslet.2013.03.018 Obrir en finestra nova
Resum
We introduce a stochastic model describing aggregation of misfolded proteins and degradation by the protein quality control system in a single cell. Aggregate growth is contrasted by the cell quality control system, that attacks them at different stages of the growth process, with an efficiency that decreases with their size. Model parameters are estimated from experimental data. Two qualitatively different behaviors emerge: a homeostatic state, where the quality control system is stable and agg...
Paraules clau
Protein Aggregation, Neurodegenerative Disease, Stochastic Dynamics, Spiky Oscillation, Proteasome-lysosome
Grup de recerca
DONLL - Dinàmica no Lineal, Òptica no Lineal i Làsers

Participants

  • Pigolotti, Simone  (autor)
  • Lizana, Ludvig  (autor)
  • Otzen, Daniel  (autor)
  • Sneppen, Kim  (autor)