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Kinetic versus energetic discrimination in biological copying

Autor
Sartori, P.; Pigolotti, S.
Tipus d'activitat
Article en revista
Revista
Physical review letters
Data de publicació
2013-05-01
Volum
110
Número
18
DOI
https://doi.org/10.1103/PhysRevLett.110.188101 Obrir en finestra nova
Projecte finançador
ESTOCASTICIDAD EN SISTEMAS COMPLEJOS NOLINEALES
URL
http://prl.aps.org/abstract/PRL/v110/i18/e188101 Obrir en finestra nova
Resum
We study stochastic copying schemes in which discrimination between a right and a wrong match is achieved via different kinetic barriers or different binding energies of the two matches. We demonstrate that, in single-step reactions, the two discrimination mechanisms are strictly alternative and cannot be mixed to further reduce the error fraction. Close to the lowest error limit, kinetic discrimination results in a diverging copying velocity and dissipation per copied bit. On the other hand, en...
Paraules clau
DNA polymerase, Error limits, Kinetic barrier, Kinetic rates, Single-step
Grup de recerca
DONLL - Dinàmica no Lineal, Òptica no Lineal i Làsers

Participants

  • Sartori, Pablo  (autor)
  • Pigolotti, Simone  (autor)