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Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice

Autor
Bai, Y.; Jones, P.; Guo, J.; Zhong, X.; Clark, R.; Zhou, Q.; Wang, R.; Vallmitjana, A.; Benitez, R.; Hove-Madsen, L.; Semeniuk, L.; Guo, A.; Song, L.; Duff, H.J.; Wayne Chen, S.R.
Tipus d'activitat
Article en revista
Revista
Circulation research
Data de publicació
2013-07-15
Volum
113
Pàgina inicial
517
Pàgina final
526
DOI
https://doi.org/10.1161/CIRCRESAHA.113.301678 Obrir en finestra nova
Projecte finançador
Aplicación de técnicas de análisis de sistemas complejos al estudio de problemas de fisiología cardíaca
Repositori
http://hdl.handle.net/2117/20251 Obrir en finestra nova
URL
http://circres.ahajournals.org/content/113/5/517.full.html?ijkey=3DrZZXugzNwB6kn&keytype=ref Obrir en finestra nova
Resum
Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ sequestration and aborts arrhythmogenic spontaneous Ca2+ waves (SCWs). An important question is whether these seemingly paradoxical effects of PLN-KO exacerbate or protect against Ca2+-triggered arrhythmias. Objective: We investigate the impact of PLN-KO on SCWs, triggered activities,...
Citació
Bai, Y. [et al.]. Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. "Circulation research", 15 Juliol 2013, vol. 113, p. 517-526.
Paraules clau
Cardiac Dynamics, Calcium Handling, Quantitative Physiology, Biomedical Signal Processing
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
CREB - Centre de Recerca en Enginyeria Biomedica

Participants

  • Bai, Yunlong  (autor)
  • Jones, Peter  (autor)
  • Guo, Jiqing  (autor)
  • Zhong, Xiaowei  (autor)
  • Clark, Robert  (autor)
  • Zhou, Qiang  (autor)
  • Wang, Ruiwu  (autor)
  • Vallmitjana Lees, Alexander  (autor)
  • Benitez Iglesias, Raul  (autor)
  • Hove-Madsen, Leif  (autor)
  • Semeniuk, Lisa  (autor)
  • Guo, Ang  (autor)
  • Song, Long-Sheng  (autor)
  • Duff, Henry J.  (autor)
  • Chen, S.R. Wayne  (autor)