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Relevance of microstructure for the early antibiotic release of fresh and pre-set calcium phosphate cements

Autor
Canal, C.; Pastorino, D.; Mestres, G.; Schuler, P.; Ginebra, M.P.
Tipus d'activitat
Article en revista
Revista
Acta biomaterialia
Data de publicació
2013
Volum
9
Número
9
Pàgina inicial
8403
Pàgina final
8412
DOI
https://doi.org/10.1016/j.actbio.2013.05.016 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/20705 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1742706113002493 Obrir en finestra nova
Resum
Calcium phosphate cements (CPCs) have great potential as carriers for controlled release and vectoring of drugs in the skeletal system. However, a lot of work still has to be done in order to obtain reproducible and predictable release kinetics. A particular aspect that adds complexity to these materials is that they cannot be considered as stable matrices, since their microstructure evolves during the setting reaction. The aims of the present work were to analyze the effect of the microstructur...
Citació
Canal, C. [et al.]. Relevance of microstructure for the early antibiotic release of fresh and pre-set calcium phosphate cements. "Acta biomaterialia", 2013, vol. 9, núm. 9, p. 8403-8412.
Paraules clau
Calcium phosphate cement Drug release Hydroxyapatite Antibiotic Doxyxycline
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants