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The mid p-value in exact tests for Hardy-Weinberg equilibrium

Autor
Graffelman, J.; Moreno, V.
Tipus d'activitat
Article en revista
Revista
Statistical applications in genetics and molecular biology
Data de publicació
2013-08-03
Volum
12
Número
4
Pàgina inicial
433
Pàgina final
448
DOI
https://doi.org/10.1515/sagmb-2012-0039 Obrir en finestra nova
URL
http://www.degruyter.com/view/j/sagmb.2013.12.issue-4/sagmb-2012-0039/sagmb-2012-0039.xml Obrir en finestra nova
Resum
Objective: Exact tests for Hardy-Weinberg equilibrium are widely used in genetic association studies. We evaluate the mid p-value, unknown in the genetics literature, as an alternative for the standard p-value in the exact test. Method: The type 1 error rate and the power of the exact test are calculated for different sample sizes, sigificance levels, minor allele counts and degrees of deviation from equilibrium. Three different p-value are considered: the standard two-sided p-value, the double...
Paraules clau
Levene-haldane Distribution, Power, Single Nucleotide Polymorphism, Type I Error Rate
Grup de recerca
LIAM - Laboratori de Modelització i Anàlisi de la Informació

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