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Noise focusing and the emergence of coherent activity in neuronal cultures

Autor
Orlandi, Javier G.; Soriano, J.; Alvarez-Lacalle, E.; Teller, S.; Casademunt, J.
Tipus d'activitat
Article en revista
Revista
Nature physics
Data de publicació
2013-07-21
Volum
9
Número
9
Pàgina inicial
582
Pàgina final
590
DOI
https://doi.org/10.1038/nphys2686 Obrir en finestra nova
URL
http://www.nature.com/nphys/journal/v9/n9/full/nphys2686.html Obrir en finestra nova
Resum
At early stages of development, neuronal cultures in vitro spontaneously reach a coherent state of collective firing in a pattern of nearly periodic global bursts. Although understanding the spontaneous activity of neuronal networks is of chief importance in neuroscience, the origin and nature of that pulsation has remained elusive. By combining high-resolution calcium imaging with modelling in silico, we show that this behaviour is controlled by the propagation of waves that nucleate randomly i...
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos

Participants

  • Gómez Orlandi, Javier  (autor)
  • Soriano Fradera, Jordi  (autor)
  • Alvarez Lacalle, Enrique  (autor)
  • Teller Amado, Sara  (autor)
  • Casademunt Viader, Jaume  (autor)