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Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior

Autor
Perrin, M.; Bauer, M.; Del Barrio, M.; Tamarit, J. Ll.; Céolin, R.; Rietveld, I.
Tipus d'activitat
Article en revista
Revista
Journal of pharmaceutical sciences
Data de publicació
2013-05-20
Volum
102
Número
7
Pàgina inicial
2311
Pàgina final
2321
DOI
https://doi.org/10.1002/jps.23612 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/21266 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/jps.23612/abstract Obrir en finestra nova
Resum
Crystalline polymorphism occurs frequently in the solid state of active pharmaceutical ingredients, and this is problematic for the development of a suitable dose form. Rimonabant, an active pharmaceutical ingredient developed by Sanofi and discontinued because of side effects, exhibits dimorphism; both solid forms have nearly the same melting temperatures, melting enthalpies, and specific volumes. Although the problem may well be academic from an industrial point of view, the present case demon...
Citació
Perrin, M. [et al.]. Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior. "Journal of Pharmaceutical Sciences", 20 Maig 2013, vol. 102, núm. 7, p. 2311-2321.
Paraules clau
Api, Polymorphism, Topological Phase Diagram, Clapeyron Equation, Crystal Structure, High Pressure, Thermal Analysis, Thermodynamics, Stability
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants