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Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)

Autor
Dávalos, A.; Alvarez-Sabin, J.; Castillo, J.; Diez, E.; Ferro, J.; Martinez-Vila , E.; Serena, J.; Segura, T.; Cruz, V.; Masjuan, J.; Cobo, E.; Secades, J.
Tipus d'activitat
Article en revista
Revista
Lancet
Data de publicació
2012-07-28
Volum
380
Número
9839
Pàgina inicial
349
Pàgina final
357
DOI
https://doi.org/10.1016/S0140-6736(12)60813-7 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0140673612608137 Obrir en finestra nova
Resum
Background Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger trial. Methods We undertook a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke admitted at university hospitals in Germany, Portugal, and Spain. Using a centralised minimisation process, patients were randomly assigne...
Grup de recerca
GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica

Participants

  • Dávalos Errando, Antoni  (autor)
  • Álvarez Sabin, José  (autor)
  • Castillo Sánchez, José  (autor)
  • Diez Tejedor, Exuperio  (autor)
  • Ferro, José  (autor)
  • Martínez Vila, Eduardo  (autor)
  • Serena Leal, Joaquín  (autor)
  • Segura Martin, Tomas  (autor)
  • Tedim Cruz, Vítor  (autor)
  • Masjuán Vallejo, Jaime  (autor)
  • Cobo Valeri, Erik  (autor)
  • Secades Ruiz, Julio José  (autor)