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Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)

Autor
Paoletti, I.; De Gregorio, V.; Baroni, A.; Tufano, M.; Donnarumma, G.; Perez, J.
Tipus d'activitat
Article en revista
Revista
Inflammation
Data de publicació
2013-12-02
Volum
36
Número
6
Pàgina inicial
1316
Pàgina final
1326
DOI
https://doi.org/10.1007/s10753-013-9670-7 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/21281 Obrir en finestra nova
URL
http://link.springer.com/article/10.1007%2Fs10753-013-9670-7 Obrir en finestra nova
Resum
Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN- γ and TNF- α -NHEK a...
Citació
Paoletti, I. [et al.]. Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat). "Inflammation", 02 Desembre 2013, vol. 36, núm. 6, p. 1316-1326.
Paraules clau
NHEK cells, amygdalin analogues, peptide T, psoriasis
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
ENGMOL - Enginyeria Molecular

Participants

  • Paoletti, Iole  (autor)
  • De Gregorio, Vicenza  (autor)
  • Baroni, Adone  (autor)
  • Tufano, Maria Antonieta  (autor)
  • Donnarumma, Giovanna  (autor)
  • Perez Gonzalez, Juan Jesus  (autor)