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Randomised study to assess the efficacy and safety of once-daily etravirine-based regimen as a switching strategy in HIV-infected patients receiving a protease inhibitor-containing regimen. Etraswitch study

Autor
Echeverria, P.; Bonjoch, A.; Puig, J.; Molto, J.; Paredes Deirós, Roger; Sirera, G.; Ornelas, A.; Perez, N.; Clotet, B.; Negredo, E.
Tipus d'activitat
Article en revista
Revista
PloS one
Data de publicació
2014-02-04
Volum
9
Número
2
DOI
https://doi.org/10.1371/journal.pone.0084676 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22665 Obrir en finestra nova
Resum
Background: Etravirine (ETR) was approved for patients with virological failure and antiretroviral resistance mutations. It has also shown antiviral efficacy in antiretroviral-naive patients. However, data on the switching from protease inhibitors (PI) to ETR are lacking.; Methods: HIV-1-infected patients with suppressed viral load (VL) during a PI-containing regimen (>12 months) and no previous virological failure were randomized to switch from the PI to ETR (400 mg/day, dissolved in water) (ET...
Citació
Echeverria, P. [et al.]. Randomised study to assess the efficacy and safety of once-daily etravirine-based regimen as a switching strategy in HIV-infected patients receiving a protease inhibitor-containing regimen. Etraswitch study. "PLoS One", 04 Febrer 2014, vol. 9, núm. 2.
Paraules clau
Antiretroviral treatment, Double-blind, Experienced HIV-1-infected patients, HDL-cholesterol, Immunodeficiency-virus-infection, Lipid profiles, Placebo-controlled trial, Reverse-transcriptase inhibitor, TMC125 etravirine, Treatment-naive patients
Grup de recerca
GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica

Participants

  • Echeverria Liras, Patricia  (autor)
  • Bonjoch Badia, Anna  (autor)
  • Puig Batalla, Jordi  (autor)
  • Molto Marhuenda, Jose  (autor)
  • Paredes Deirós, Roger  (autor)
  • Sirera Jimenez, Guillem  (autor)
  • Ornelas Vargas, Arelly  (autor)
  • Perez Alvarez, Nuria  (autor)
  • Clotet Sala, Bonaventura  (autor)
  • Negredo Puigmal, Eugènia  (autor)

Arxius