Carregant...
Carregant...

Vés al contingut (premeu Retorn)

The smallest peptoids with antiproliferative activity on human neoplastic cells

Autor
Mas-Moruno, C.; Cruz, L.J.; Mora, P.; Francesch, A.; Messeguer, A.; Perez, E.; Albericio, F.
Tipus d'activitat
Article en revista
Revista
Journal of medicinal chemistry
Data de publicació
2007
Volum
50
Pàgina inicial
2443
Pàgina final
2449
DOI
https://doi.org/10.1021/jm061166z Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22772 Obrir en finestra nova
URL
http://pubs.acs.org/doi/abs/10.1021/jm061166z Obrir en finestra nova
Resum
Libraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis
Citació
Mas-Moruno, C. [et al.]. The smallest peptoids with antiproliferative activity on human neoplastic cells. "Journal of medicinal chemistry", 2007, vol. 50, p. 2443-2449.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Mas Moruno, Carlos  (autor)
  • Cruz, Luis Javier  (autor)
  • Mora, Pablo  (autor)
  • Francesch, A  (autor)
  • Messeguer, A  (autor)
  • Perez Paya, Enrique  (autor)
  • Albericio Palomera, Fernando  (autor)