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Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes a5ß1 and avß6: conformational control through flanking amino acids

Autor
Bochen, A.; Marelli, U.; Otto, E.; Pallarola, D.; Mas-Moruno, C.; Di Leva, F.S.; Boehm, H.; Spatz, J.P.; Novellino, E.; Kessler, H.; Marinelli, L.
Tipus d'activitat
Article en revista
Revista
Journal of medicinal chemistry
Data de publicació
2013
Volum
56
Número
4
Pàgina inicial
1509
Pàgina final
1519
DOI
https://doi.org/10.1021/jm301221x Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22775 Obrir en finestra nova
URL
http://pubs.acs.org/doi/abs/10.1021/jm301221x Obrir en finestra nova
Resum
Integrins are the major class of cell adhesion proteins. Their interaction with different ligands of the extracellular matrix is diverse. To get more insight into these interactions, artificial ligands endowed with a well-defined activity/selectivity profile are necessary. Herein, we present a library of cyclic pentapeptides, based on our previously reported peptide motif c(-phg-isoDGR-X-), in which high activity toward fibronectin binding integrins a5ß1 and avß6 and not on vitronectin binding...
Citació
Bochen, A. [et al.]. Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes a5ß1 and avß6: conformational control through flanking amino acids. "Journal of medicinal chemistry", 2013, vol. 56, núm. 4, p. 1509-1519.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Bochen, Alexander  (autor)
  • Marelli, Udaya Kiran  (autor)
  • Otto, Elke  (autor)
  • Pallarola, Diego  (autor)
  • Mas Moruno, Carlos  (autor)
  • Di Leva, Francisco Saverio  (autor)
  • Boehm, Heike  (autor)
  • Spatz, Joaquim P.  (autor)
  • Novellino, Ettore  (autor)
  • Kessler, Horst  (autor)
  • Marinelli, Luciana  (autor)