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Cyclic azapeptide integrin ligand synthesis and biological activity

Autor
Spiegel, J.; Mas-Moruno, C.; Kessler, H.; Lubell, W.D.
Tipus d'activitat
Article en revista
Revista
Journal of organic chemistry
Data de publicació
2012
Volum
77
Número
12
Pàgina inicial
5271
Pàgina final
5278
DOI
https://doi.org/10.1021/jo300311q Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22781 Obrir en finestra nova
URL
http://pubs.acs.org/doi/abs/10.1021/jo300311q Obrir en finestra nova
Resum
Aza-peptides are obtained by replacement of the α-C-atom of one or more amino acids by a nitrogen atom in a peptide sequence. Introduction of aza-residues into peptide sequences may result in unique structural and pharmacological properties, such that aza-scanning may be used to probe structure–activity relationships. In this study, a general approach for the synthesis of cyclic aza-peptides was developed by modification of strategies for linear aza-peptide synthesis and applied in the prepar...
Citació
Spiegel, J. [et al.]. Cyclic azapeptide integrin ligand synthesis and biological activity. "Journal of organic chemistry", 2012, vol. 77, núm. 12, p. 5271-5278.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Spiegel, Jochen  (autor)
  • Mas Moruno, Carlos  (autor)
  • Kessler, Horst  (autor)
  • Lubell, W.D.  (autor)