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Conformational control of integrin subtype selectivity in isoDGR peptide motifs: A biological switch

Autor
Frank, A.O.; Otto, E.; Mas-Moruno, C.; Schiller, H.; Marinelli, L.; Cosconati, S.; Bochen, A.; Vossmeyer, D.; Zahn, G.; Stragies, R.; Novellino, E.; Kessler, H.
Tipus d'activitat
Article en revista
Revista
Angewandte chemie. International edition
Data de publicació
2010
Volum
49
Número
48
Pàgina inicial
9278
Pàgina final
9281
DOI
https://doi.org/10.1002/anie.201004363 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22807 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/anie.201004363/abstract Obrir en finestra nova
Resum
Thumbnail image of graphical abstract The rearrangement of asparagine to isoaspartate (isoD) is responsible for the deactivation of many functional proteins. However, the isoDGR motif, which is optimally presented as a conformationally controlled cyclic pentapeptide, binds selectively to a5ß1 integrin (see the docking model) with an affinity comparable to that of the peptidic antitumor agent Cilengitide
Citació
Frank, A.O. [et al.]. Conformational control of integrin subtype selectivity in isoDGR peptide motifs: A biological switch. "Angewandte chemie. International edition", 2010, vol. 49, núm. 48, p. 9278-9281.
Paraules clau
NMR spectroscopy, cyclic pentapeptides, integrin ligands, isoDGR sequence, peptides
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Frank, A.O.  (autor)
  • Otto, E.  (autor)
  • Mas Moruno, Carlos  (autor)
  • Schiller, H.  (autor)
  • Marinelli, L.  (autor)
  • Cosconati, S.  (autor)
  • Bochen, Alexander  (autor)
  • Vossmeyer, D.  (autor)
  • Zahn, G.  (autor)
  • Stragies, R.  (autor)
  • Novellino, E.  (autor)
  • Kessler, Horst  (autor)