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Trivalent PEGylated platform for the conjugation of bioactive compounds

Autor
Torres, Á.; Mas-Moruno, C.; Perez, E.; Albericio, F.; Royo, M.
Tipus d'activitat
Article en revista
Revista
Bioconjugate chemistry
Data de publicació
2011
Volum
22
Número
10
Pàgina inicial
2172
Pàgina final
2178
DOI
https://doi.org/10.1021/bc100393g Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22808 Obrir en finestra nova
URL
http://pubs.acs.org/doi/abs/10.1021/bc100393g Obrir en finestra nova
Resum
PEGylated multivalent structures are a new class of platform for biological applications due to their biocompatibility properties. Here, we present the synthesis of a trivalent structure 1 based on poly(ethylene glycol) units (PEG) as potential synthetic multifunctional carrier molecule. To evaluate whether this PEGylated platform could be useful for the conjugation of bioactive compounds, a well-known lipopolysaccharide (LPS) inhibitor 2, developed in our laboratory, was selected to be conjugat...
Citació
Torres, A. [et al.]. Trivalent PEGylated platform for the conjugation of bioactive compounds. "Bioconjugate chemistry", 2011, vol. 22, núm. 10, p. 2172-2178.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Torres, Ángela  (autor)
  • Mas Moruno, Carlos  (autor)
  • Perez Paya, Enrique  (autor)
  • Albericio Palomera, Fernando  (autor)
  • Royo, M.  (autor)