Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Complexes of polyglutamic acid and long-chain alkanoylcholines: Nanoparticle formation and drug release

Autor
Tolentino, A.; Alla, A.; Martinez de Ilarduya, A.; Muñoz, S.
Tipus d'activitat
Article en revista
Revista
International journal of biological macromolecules
Data de publicació
2014-05-01
Volum
66
Pàgina inicial
346
Pàgina final
353
DOI
https://doi.org/10.1016/j.ijbiomac.2014.02.043 Obrir en finestra nova
Projecte finançador
Bioplásticos Derivados de Carbohidratos y Biopolímeros Microbianos para Aplicaciones en Envasado y Farmacia
Bioplásticos derivados de carbohidratos para envasado y farmacia. Subproyecto II.
Repositori
http://hdl.handle.net/2117/22946 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0141813014001275?via=ihub Obrir en finestra nova
Resum
Ionic complexes of microbial poly(¿-glutamic acid) and alkanoylcholines are fully bio-based comb-like systems able to self-organize in an ordered amphiphilic structure made of hydrophobic and hydrophilic alternating layers. Incubation of complex films under physiological conditions for one month promoted dissociation of the complex and hydrolysis of the choline ester without almost degradation of polyglutamic acid. Complex decomposition rates were depending on alkanoyl chain length and on compl...
Citació
Tolentino, A. [et al.]. Complexes of polyglutamic acid and long-chain alkanoylcholines: Nanoparticle formation and drug release. "International journal of biological macromolecules", 01 Maig 2014, vol. 66, p. 346-353.
Paraules clau
Complexes, alkanoylcholines, drug delivery, nanoparticles, poly(gamma-glutamic acid)
Grup de recerca
POL - Polímers Industrials Avançats i Biopolímers Tecnològics

Participants