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Designing type II topoisomerase inhibitors: a molecular modeling approach

Autor
Perez, J.; Lupala, C.; Gomez, P.
Tipus d'activitat
Article en revista
Revista
Current topics in medicinal chemistry
Data de publicació
2014-01-07
Volum
14
Número
1
Pàgina inicial
40
Pàgina final
50
DOI
https://doi.org/10.2174/1568026613666131113150046 Obrir en finestra nova
URL
http://eurekaselect.com/117935 Obrir en finestra nova
Resum
Nosocomial infections are produced by pathogens with the ability to persist in hospital environments and with the propensity to develop resistance to diverse antimicrobials. In order to tackle resistance, it has been pointed as good strategy to select resilient drug targets that are evolutionally constrained to design drugs less susceptible to develop resistance. Molecular modeling can help to fulfill this goal by providing a rationalization of the observed resistance at the molecular level and,...
Paraules clau
Antibiotics Design, Nosocomial Infections, Quinolones, Topoisomerases Inhibitors
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
ENGMOL - Enginyeria Molecular

Participants