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Molecular characterization of L-phenylalanine terminated poly(L-lactide) conjugates

Autor
Murase, S. K.; Haspel; del Valle, LJ.; Perpète, Eric A.; Nussinov, R.; Michaux, Catherine Anne Gisèle; Puiggali, J.; Aleman, C.
Tipus d'activitat
Article en revista
Revista
RSC advances
Data de publicació
2014-05-15
Número
44
Pàgina inicial
23231
Pàgina final
23241
DOI
https://doi.org/10.1039/C4RA01534G Obrir en finestra nova
URL
http://pubs.rsc.org/en/Content/ArticleLanding/2014/RA/c4ra01534g#!divAbstract Obrir en finestra nova
Resum
Peptide–polymer conjugates made of poly(L-lactide) and L-phenylalanine or L,L-diphenylalanine (F–PLA and FF–PLA, respectively) have been synthesized by the ring-opening polymerization of L-lactide using the peptide fragment as an initiator. The structure of the conjugates was confirmed by 1H NMR, FT-IR, GPC, UV-Vis and CD. Molecular dynamics simulations have been used to identify both the conformational preferences of the FF–PLA conjugate in solution and the potential intramolecular inte...
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.

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