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Extracellular calcium and CaSR drive osteoinduction in mesenchymal stromal cells

Autor
Gonzalez, A.; Planell, J. A.; Engel, E.
Tipus d'activitat
Article en revista
Revista
Acta biomaterialia
Data de publicació
2014-06-01
Volum
10
Número
6
Pàgina inicial
2824
Pàgina final
2833
DOI
https://doi.org/10.1016/j.actbio.2014.02.004 Obrir en finestra nova
Projecte finançador
Diseño y desarrollo de biomateriales bioactivos para la regeneración de la piel basada en la señalización controlada de liberación de iones
Repositori
http://hdl.handle.net/2117/23357 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1742706114000567# Obrir en finestra nova
Resum
Bone is the main store of calcium and progenitor cells in the body. During the resorption process, the local calcium concentration reaches 8-40 mM, and the surrounding cells are exposed to these fluctuations in calcium. This stimulus is a signal that is detected through the calcium sensing receptor (CaSR), which modulates chemotactic and proliferative G protein-dependent signaling pathways. The objective of the present work is to evaluate the roles of extracellular calcium ([Ca2+](o)) and the Ca...
Citació
Gonzalez, A.; Planell, J.; Engel, E. Extracellular calcium and CaSR drive osteoinduction in mesenchymal stromal cells. "Acta biomaterialia", 01 Juny 2014, vol. 10, núm. 6, p. 2824-2833.
Paraules clau
Calcium Sensing Receptor (casr), Extracellular Calcium, Mesenchymal Stromal Cells (mscs), Osteoinduction, Regenerative Medicine, Sensing-receptor, Bone-marrow, Stem-cells, In-vitro, Osteoblast Function, Mc3t3-e1 Cells, Differentiation, Proliferation, Expression, Tissue
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica

Participants