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Restricted puckering of mineralized RNA-like riboses

Autor
Casanovas Salas, Jordi; Revilla-López, G.; Bertran, O.; del Valle, LJ.; Turon, P.; Puiggali, J.; Aleman, C.
Tipus d'activitat
Article en revista
Revista
Journal of physical chemistry B
Data de publicació
2014-05-15
Volum
118
Número
19
Pàgina inicial
5075
Pàgina final
5081
DOI
https://doi.org/10.1021/jp501714q Obrir en finestra nova
Projecte finançador
Nuevos polímeros derivados de lactida: estructura, aplicaciones biomédicas y microprocesado.
POLIMEROS CONDUCTORES Y SUS DERIVADOS HIBRIDOS CON APLICACIONES AVANZADAS
URL
http://pubs.acs.org/doi/abs/10.1021/jp501714q Obrir en finestra nova
Resum
The pseudorotational motions of highly hydroxylated pentafuranose sugars in the free state and tethered to hydroxyapatite have been compared. The conformation pentafuranose ring remains restricted at the North region of the pseudorotational wheel, which is the one typically observed for nucleosides and nucleotides in the double helix A-RNA, when the phosphate-bearing sugar is anchored to the mineral surface. Results indicate that the severe restrictions imposed by the mineral are responsible of ...
Paraules clau
ANGSTROM RESOLUTION, BASIS-SETS, CONFORMATIONAL-ANALYSIS, COUPLING-CONSTANTS, DNA, FORCE-FIELD, GLYCOSIDIC BOND, MOLECULAR-DYNAMICS, NUCLEOSIDES, SUGAR RING
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.

Participants