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Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model

Autor
Lugo, C.A.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Hove-Madsen, L.; Echebarria, B.
Tipus d'activitat
Article en revista
Revista
American journal of physiology. Heart and circulatory physiology
Data de publicació
2014-06-01
Volum
306
Número
11
Pàgina inicial
H1540
Pàgina final
H1552
DOI
https://doi.org/10.1152/ajpheart.00515.2013 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/23521 Obrir en finestra nova
Resum
Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum (SR) Ca loading. However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). We have investigated the effect of ...
Citació
Lugo, C.A. [et al.]. Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model. "American journal of physiology. Heart and circulatory physiology", 01 Juny 2014, vol. 306, núm. 11, p. H1540-H1552.
Paraules clau
CALCIUM, CONTRACTION, FIBRILLATION, HEART-FAILURE, MATHEMATICAL-MODEL, RELEASE, REPOLARIZATION ALTERNANS, SARCOPLASMIC-RETICULUM, SR calcium release refractoriness, T-TUBULES, VENTRICULAR MYOCYTES, arrhythmias, calcium dynamics, electromechanical alternans, ryanodine receptor
Grup de recerca
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació

Participants