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In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27

Autor
Acosta, F.J.; Dardonville, C.; De Koning, H.; Natto, M.; Subirana, J.; Campos, J.Lourdes
Tipus d'activitat
Article en revista
Revista
Acta crystallographica section D: Biological crystallography
Data de publicació
2014-06
Volum
70
Número
6
Pàgina inicial
1614
Pàgina final
1621
DOI
https://doi.org/10.1107/S139900471400697X Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/23505 Obrir en finestra nova
URL
http://scripts.iucr.org/cgi-bin/paper?S139900471400697X Obrir en finestra nova
Resum
The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies of drugs which interact with the minor groove of DNA, some of which are used in medical practice. Previous studies have been performed almost exclusively with the AATT sequence. New features should be uncovered through the study of different DNA sequences. In this paper, the c...
Citació
Acosta, F.J. [et al.]. In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27. "Acta Crystallographica Section D: Biological Crystallography", Juny 2014, vol. 70, núm. 6, p. 1614-1621.
Paraules clau
AT-rich DNA, CD27, d(AAAATTTT, minor-groove binding drug
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques

Participants

  • Acosta Reyes, Francisco Javier  (autor)
  • Dardonville, Cristophe Y.  (autor)
  • De Koning, Harry Pieter  (autor)
  • Natto, Manal J.  (autor)
  • Subirana, Juan Antonio  (autor)
  • Campos Lopez, Josefa de Lourdes  (autor)

Arxius