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Covalent immobilization of hLf1-11 peptide on a titanium surface reduces bacterial adhesion and biofilm formation

Autor
Godoy, M.; Mas-Moruno, C.; Fernandez, M.; Perez-Giraldo, C.; Manero, J.; Albericio, F.; Gil, F.J.; Rodriguez, D.
Tipus d'activitat
Article en revista
Revista
Acta biomaterialia
Data de publicació
2014-08-01
Volum
10
Número
8
Pàgina inicial
3522
Pàgina final
3534
DOI
https://doi.org/10.1016/j.actbio.2014.03.026 Obrir en finestra nova
Projecte finançador
NUEVOS BIOMATERIALES METALICOS BIOFUNCIONALIZADOS PARA APLICACIONES ORTOPEDICAS,
Repositori
http://hdl.handle.net/2117/24128 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1742706114001469# Obrir en finestra nova
Resum
Bacterial infection represents a major cause of implant failure in dentistry. A common approach to overcoming this issue and treating pen-implant infection consists in the use of antibiotics. However, the rise of multidrug-resistant bacteria poses serious concerns to this strategy. A promising alternative is the use of antimicrobial peptides due to their broad-spectrum activity against bacteria and reduced bacterial resistance responses. The aim of the present study was to determine the in vitro...
Citació
Godoy, M. [et al.]. Covalent immobilization of hLf1-11 peptide on a titanium surface reduces bacterial adhesion and biofilm formation. "Acta biomaterialia", 01 Agost 2014, vol. 10, núm. 8, p. 3522-3534.
Paraules clau
ANTIMICROBIAL PEPTIDES, Antimicrobial peptide, Bacterial adhesion, Biofunctionalization, CANDIDA-ALBICANS, CELL-ADHESIVE, ESCHERICHIA-COLI, GOLD SURFACES, HUMAN LACTOFERRIN, IMPLANTS, IN-VITRO, Lactoferrin peptide, RAY PHOTOELECTRON-SPECTROSCOPY, THIOL, Titanium
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants