Carregant...
Carregant...

Vés al contingut (premeu Retorn)

The integrin ligand c(RGDf(NMe)Nal) reduces neointimal hyperplasia in a polymer-free drug-eluting stent system

Autor
Rechenmacher, F.; Steigerwald, K.; Laufer, B.; Neubauer, S.; Kapp, T.; Li, L.; Mas-Moruno, C.; Joner, M.; Kessler, H.
Tipus d'activitat
Article en revista
Revista
Chemmedchem
Data de publicació
2014-07-01
Volum
9
Número
7
Pàgina inicial
1413
Pàgina final
1418
DOI
https://doi.org/10.1002/cmdc.201400078 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/24126 Obrir en finestra nova
Resum
The use of highly active and selective integrin ligands in combination with stent implantation is emerging as a promising alternative to the release of classical immunosuppressive drugs by current drug-eluting stents (DES), which has been associated with delayed vascular healing and late stent thrombosis. Herein we present the development and biological evaluation of the integrin ligand c(RGDf(NMe)Nal) as a potent anti-proliferative molecule that targets coronary artery smooth muscle cells (CASM...
Citació
Rechenmacher, F. [et al.]. The integrin ligand c(RGDf(NMe)Nal) reduces neointimal hyperplasia in a polymer-free drug-eluting stent system. "Chemmedchem", 01 Juliol 2014, vol. 9, núm. 7, p. 1413-1418.
Paraules clau
Drug-eluting Stents, Integrin Ligands, Myocardial Infarction, Peptides, Rgd, Smooth Muscle Cells, Cyclic-rgd Peptide, Alpha(v)beta(3) Integrin, Biological Evaluation, Vasomotor Function, Permanent Polymer, Porcine Model, Antagonists, Alpha-v-beta-3, Sirolimus, Selectivity
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Rechenmacher, Florian  (autor)
  • Steigerwald, Kristin  (autor)
  • Laufer, Burkhardt  (autor)
  • Neubauer, Stefanie  (autor)
  • Kapp, Tobias G.  (autor)
  • Li, Liang  (autor)
  • Mas Moruno, Carlos  (autor)
  • Joner, Michael  (autor)
  • Kessler, Horst  (autor)