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The impact of amino acid side chain mutations in conformational design of peptides and proteins

Autor
Laufer, B.; Frank, A.; Chatterjee, J.; Neubauer, T.; Mas-Moruno, C.; Kummerlöwe, G.; Kessler, H.
Tipus d'activitat
Article en revista
Revista
Chemistry: a european journal
Data de publicació
2010
Volum
16
Número
18
Pàgina inicial
5385
Pàgina final
5390
DOI
https://doi.org/10.1002/chem.201000545 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/24098 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/chem.201000545/abstract Obrir en finestra nova
Resum
Local energetic effects of amino acid replacements are often considered to have only a moderate influence on the backbone conformation of proteins or peptides. As these effects are difficult to determine experimentally, no comparison has yet been performed. However, knowledge of the influence of side chain mutations is essential in protein homology modeling and in optimizing biologically active peptide ligands in medicinal chemistry. Furthermore, the tool of N-methylation of peptides is of incre...
Citació
Laufer, B. [et al.]. The impact of amino acid side chain mutations in conformational design of peptides and proteins. "Chemistry: a european journal", 2010, vol. 16, núm. 18, p. 5385-5390.
Paraules clau
amino acids, conformation analysis, methylation, peptides, spatial screening
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Laufer, B.  (autor)
  • Frank, A.O.  (autor)
  • Chatterjee, J.  (autor)
  • Neubauer, T.  (autor)
  • Mas Moruno, Carlos  (autor)
  • Kummerlöwe, G.  (autor)
  • Kessler, Horst  (autor)