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Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces

Autor
Joner, M.; Cheng, Q.; Schönhofer-Merl, S.; Lopez, M.; Neubauer, S.; Mas-Moruno, C.; Laufer, B.; Kolodgie, F.; Kessler, H.; Virmani, R.
Tipus d'activitat
Article en revista
Revista
Journal of biomedical materials research. Part B, Applied biomaterials
Data de publicació
2012
Volum
100
Número
3
Pàgina inicial
637
Pàgina final
645
DOI
https://doi.org/10.1002/jbm.b.31988 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/24096 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31988/abstract;jsessionid=6DE4D9A00EAF5E7CDB8678B6FBEE97EC.f02t02 Obrir en finestra nova
Resum
This study examined the utility of a stabilized cyclic RGD peptide chemically modified to selectively bind to titanium-oxide for enhanced biocompatibility of self-expanding nitinol stents. Endothelial cells express integrin receptors that promote attachment to subendothelial matrix proteins. Integrin binding to arginine-glycine-aspartic acid (RGD) peptide derivatives mimic naturally occurring adherent interactions. Irreversible covalent surface coating of conventional nitinol stents with a cycli...
Citació
Joner, M. [et al.]. Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces. "Journal of Biomedical Materials Research Part B: Applied Biomaterials", 2012, vol. 100, núm. 3, p. 637-645.
Paraules clau
Endothelial Cells, Focal Adhesion Kinase, Nitinol, Rgd Peptide, Self-expanding Stent
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Joner, M.  (autor)
  • Cheng, Q.  (autor)
  • Schönhofer-Merl, S.  (autor)
  • Lopez, M.  (autor)
  • Neubauer, Stefanie  (autor)
  • Mas Moruno, Carlos  (autor)
  • Laufer, B.  (autor)
  • Kolodgie, F.D.  (autor)
  • Kessler, Horst  (autor)
  • Virmani, R.  (autor)