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Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery

Autor
Martin, I.; Dohmen , C.; Mas-Moruno, C.; Troiber, C.; Kos, P.; Schaffert, D.; Lächelt, U.; Teixidó, M.; Günther, M.; Kessler, H.; Giralt, E.; Wagner, E.
Tipus d'activitat
Article en revista
Revista
Organic and biomolecular chemistry
Data de publicació
2012
Volum
10
Número
16
Pàgina inicial
3258
Pàgina final
3268
DOI
https://doi.org/10.1039/c2ob06907e Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/24095 Obrir en finestra nova
URL
http://pubs.rsc.org/en/Content/ArticleLanding/2012/OB/c2ob06907e#!divAbstract Obrir en finestra nova
Resum
In the forthcoming era of cancer gene therapy, efforts will be devoted to the development of new efficient and non-toxic gene delivery vectors. In this regard, the use of Fmoc/Boc-protected oligo(ethane amino)acids as building blocks for solid-phase-supported assembly represents a novel promising approach towards fully controlled syntheses of effective gene vectors. Here we report on the synthesis of defined polymers containing the following: (i) a plasmid DNA (pDNA) binding domain of eight succ...
Citació
Martin, I. [et al.]. Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. "Organic and biomolecular chemistry", 2012, vol. 10, núm. 16, p. 3258-3268.
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Martin Badajoz, Irene  (autor)
  • Dohmen, C.  (autor)
  • Mas Moruno, Carlos  (autor)
  • Troiber, C.  (autor)
  • Kos, P.  (autor)
  • Schaffert, D.  (autor)
  • Lächelt, U.  (autor)
  • Teixidó, M.  (autor)
  • Günther, M.  (autor)
  • Kessler, Horst  (autor)
  • Giralt, E.  (autor)
  • Wagner, E.  (autor)

Arxius