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Long non-coding RNAs as a source of new peptides

Autor
Ruiz, J.; Messeguer, X.; Subirana, J.; Albà, M.
Tipus d'activitat
Article en revista
Revista
eLife
Data de publicació
2014-09-16
Volum
3
Pàgina inicial
1
Pàgina final
24
DOI
https://doi.org/10.7554/eLife.03523 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/24421 Obrir en finestra nova
URL
https://elifesciences.org/content/3/e03523 Obrir en finestra nova
Resum
Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribo...
Citació
Ruiz, J. [et al.]. Long non-coding RNAs as a source of new peptides. "eLife", 16 Setembre 2014, vol. 3, p. 1-24.
Paraules clau
Open Reading Frames, Polycistronic Messenger-rna, Transcriptional Landscape, Saccaromyces-cerevisiae, Gene-expression, Disease Genes, Human-cells, Evolution, Reveals
Grup de recerca
ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals
CEBIM - Centre de Biotecnologia Molecular

Participants