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G-protein-coupled receptors oligomerization: emerging signaling units and new opportunities for drug design

Autor
Tena, M.; Ramon, E.; Rivera, D.; Borroto, D.; Romero, W.; Fuxe, K.; Garriga, P.
Tipus d'activitat
Article en revista
Revista
Current protein and peptide science
Data de publicació
2014-01-01
Volum
15
Número
7
Pàgina inicial
648
Pàgina final
658
DOI
https://doi.org/10.2174/1389203715666140901094248 Obrir en finestra nova
URL
http://www.eurekaselect.com/124291/article Obrir en finestra nova
Resum
G-protein-coupled receptors (GPCRs) are a widespread family of transmembrane receptors with different physiologically relevant functions. Alterations in the structure and function of these receptors at different levels (ligand binding, signaling and trafficking) may result in a number of pathological conditions which represent a major health problem. Mutations in these receptors are also linked to different inherited diseases for which there is no cure to date. Rationale design, based on recepto...
Paraules clau
Dimers, Disease, Drug Design, G-protein-coupled Receptors, Ligand, Oligomerization, Adenosine A(2a) Receptors, Mu-opioid Receptor, Chemokine Receptor, Dopamine-d-2 Receptors, Transmembrane Helices, Quaternary Structure, Proximity Ligation, Living Cells, Dimerization, Identification
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants

  • Tena Campos, Merce  (autor)
  • Ramon Portés, Eva  (autor)
  • Rivera Rodriguez, Diana Marcela  (autor)
  • Borroto Escuela, Dasiel Óscar  (autor)
  • Romero Fernández, Wilber  (autor)
  • Fuxe, Kjell  (autor)
  • Garriga Sole, Pere  (autor)