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Polymorphic crystal structures of an all-AT DNA dodecamer

Autor
Acosta, F.J.; Subirana, J.; Pous, J.; Sanchez-Giraldo,R; Condom, N.; Baldini, R.; Campos, J.Lourdes; Malinina, L.
Tipus d'activitat
Article en revista
Revista
Biopolymers
Data de publicació
2015-03
Volum
103
Número
3
Pàgina inicial
123
Pàgina final
133
DOI
https://doi.org/10.1002/bip.22565 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/bip.22565/abstract Obrir en finestra nova
Resum
In this work, we explore the influence of different solvents and ions on the crystallization behavior of an all-AT dodecamer d(AATAAATTTATT)2 In all cases, the oligonucleotides are found as continuous columns of stacked duplexes. The spatial organization of such columns is variable; consequently we have obtained seven different crystal forms. The duplexes can be made to crystallize in either parallel or crossed columns. Such versatility in the formation of a variety of crystal forms is character...
Paraules clau
AT-rich DNA, DNA, X-ray crystallography, crossed DNA structures, inorganic cations, liquid crystals, oligonucleotides
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques

Participants

  • Acosta Reyes, Francisco Javier  (autor)
  • Subirana, Juan Antonio  (autor)
  • Pous, Joan  (autor)
  • Sanchez-Giraldo, Raquel  (autor)
  • Condom, Núria  (autor)
  • Baldini, Roberto  (autor)
  • Campos Lopez, Josefa de Lourdes  (autor)
  • Malinina, Lucy  (autor)