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Stop-and-go kinetics in amyloid fibrillation

Autor
Ferkinghoff-Borg, J.; Fonslet, J.; Beyschau, C.; Krishna, S.; Pigolotti, S.; Yagi, H.; Goto, Y.; Otzen, D.; Jensen, Mogens H.
Tipus d'activitat
Article en revista
Revista
Physical review E: statistical, nonlinear, and soft matter physics
Data de publicació
2010-07-01
Volum
82
Pàgina inicial
010901-1
Pàgina final
010901-4
DOI
https://doi.org/10.1103/PhysRevE.82.010901 Obrir en finestra nova
URL
http://journals.aps.org/pre/abstract/10.1103/PhysRevE.82.010901 Obrir en finestra nova
Resum
Many human diseases are associated with protein aggregation and fibrillation. We present experiments on in vitro glucagon fibrillation using total internal reflection fluorescence microscopy, providing real-time measurements of single-fibril growth. We find that amyloid fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. The observed exponential distributions of stop and growth times support a Markovian model, in which fibrils shift between the two states wit...
Grup de recerca
DONLL - Dinàmica no Lineal, Òptica no Lineal i Làsers

Participants

  • Ferkinghoff-Borg, Jesper  (autor)
  • Fonslet, Jesper  (autor)
  • Beyschau Andersen, Christian  (autor)
  • Krishna, Sandeep  (autor)
  • Pigolotti, Simone  (autor)
  • Yagi, Hisashi  (autor)
  • Goto, Yuji  (autor)
  • Otzen, Daniel  (autor)
  • Jensen, Mogens H.  (autor)