Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Modeling proteasome dynamics in Parkinson's disease

Autor
Sneppen, K.; Lizana, L.; Jensen, Mogens H.; Pigolotti, S.; Otzen, D.
Tipus d'activitat
Article en revista
Revista
Physical biology
Data de publicació
2009-05-01
Volum
6
Número
3
Pàgina inicial
036005-1
Pàgina final
036005-10
DOI
https://doi.org/10.1088/1478-3975/6/3/036005 Obrir en finestra nova
URL
http://iopscience.iop.org/1478-3975/6/3/036005 Obrir en finestra nova
Resum
In Parkinson's disease (PD), there is evidence that a-synuclein (aSN) aggregation is coupled to dysfunctional or overburdened protein quality control systems, in particular the ubiquitin–proteasome system. Here, we develop a simple dynamical model for the on-going conflict between aSN aggregation and the maintenance of a functional proteasome in the healthy cell, based on the premise that proteasomal activity can be titrated out by mature aSN fibrils and their protofilament precursors. In the ...
Grup de recerca
DONLL - Dinàmica no Lineal, Òptica no Lineal i Làsers

Participants

  • Sneppen, Kim  (autor)
  • Lizana, Ludvig  (autor)
  • Jensen, Mogens H.  (autor)
  • Pigolotti, Simone  (autor)
  • Otzen, Daniel  (autor)