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Cardiac contraction induces discordant alternans and localized block

Autor
Radszuweit, M.; Alvarez-Lacalle, E.; Bär, M.; Echebarria, B.
Tipus d'activitat
Article en revista
Revista
Physical review E: statistical, nonlinear, and soft matter physics
Data de publicació
2015-02-04
Volum
91
Número
2
DOI
https://doi.org/10.1103/PhysRevE.91.022703 Obrir en finestra nova
Projecte finançador
Modeling excitation-contraction coupling in the heart
Modelización de dinámica cardiaca a distintas escalas
Repositori
http://hdl.handle.net/2117/28119 Obrir en finestra nova
Resum
In this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e., alternations in the duration of the cardiac action potential, that occur at fast pacing rates and are known to be proarrhythmic. We show that small stretch-activated currents can produce large effects and cause a transition from in-phase to off-phase alternations (i.e., from concordant to discordant alternans) and to conduction blocks. W...
Citació
Radszuweit, M. [et al.]. Cardiac contraction induces discordant alternans and localized block. "Physical review E: statistical, nonlinear, and soft matter physics", 04 Febrer 2015, vol. 91, núm. 2.
Paraules clau
ELECTRICAL ALTERNANS, EXCITABLE MEDIA, FIBRILLATION, MECHANISMS, MECHANOELECTRIC FEEDBACK, SPIRAL WAVES, STRETCH-INDUCED CHANGES, T-WAVE, TISSUE, VULNERABILITY
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos

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